| Pitcher's Name | Strikeouts |
| Gerrit Cole | 690 |
| Justin Verlander | 687 |
| Zack Greinke | 334 |
| Wade Miley | 211 |
| Charlie Morton | 196 |
| Lance McCullers | 179 |
| Dallas Keuchel | 162 |
| Brad Peacock | 113 |
| Christian Javier | 34 |
| Framber Valdez | 33 |
| Roberto Osuna | 20 |
| Will Harris | 10 |
| Hector Rondon | 9 |
| Jose Urquidy | 7 |
| Enoli Paredes | 7 |
| Ryan Pressly | 1 |
| Joe Smith | 1 |
| Colin McHugh | 1 |
| Tony Sipp | 0 |
| Cy Sneed | 0 |
| Blake Taylor | 0 |
| Andre Scrubb | |
