| Pitcher's Name | Innings | Earned Runs | ERA |
| Roberto Osuna | 56.2 | 27 | 4.96 |
| Blake Taylor | 2.1 | 1 | 4.29 |
| Justin Verlander | 563.1 | 213 | 3.40 |
| Jose Urquidy | 109.0 | 41 | 3.39 |
| Wade Miley | 297.0 | 107 | 3.24 |
| Christian Javier | 108.1 | 36 | 3.00 |
| Zack Greinke | 403.0 | 130 | 2.90 |
| Gerrit Cole | 583.0 | 183 | 2.83 |
| Cy Sneed | 3.2 | 1 | 2.81 |
| Brad Peacock | 267.1 | 80 | 2.70 |
| Dallas Keuchel | 278.2 | 81 | 2.62 |
| Charlie Morton | 281.0 | 73 | 2.34 |
| Ryan Pressly | 12.0 | 3 | 2.25 |
| Joe Smith | 5.0 | 1 | 1.80 |
| Lance McCullers | 399.0 | 63 | 1.42 |
| Framber Valdez | 106.0 | 16 | 1.36 |
| Will Harris | 27.2 | 4 | 1.32 |
| Hector Rondon | 24.1 | 2 | 0.75 |
| Tony Sipp | 5.0 | 0 | 0.00 |
| Colin McHugh | 3.0 | 0 | 0.00 |
| Andre Scrubb | 7.0 | 0 | 0.00 |
| Enoli Paredes | 14.0 | 0 | 0.00 |
