| Player's Name | Runs |
| Alex Bregman | 201 |
| Jose Altuve | 197 |
| George Springer | 185 |
| Yuli Gurriel | 182 |
| Carlos Correa | 166 |
| Josh Reddick | 132 |
| Michael Brantley | 110 |
| Yordan Alvarez | 85 |
| Evan Gattis | 74 |
| Robinson Chirinos | 57 |
| Brian McCann | 26 |
| Kyle Tucker | 22 |
| Jake Marisnick | 20 |
| Max Stassi | 18 |
| Martin Maldonado | 16 |
| Tyler White | 7 |
| Aledmys Diaz | 5 |
| Tony Kemp | 3 |
| Marwin Gonzalez | 1 |
| J.D. Davis | 1 |
| Derek Fisher | 1 |
| Taylor Jones | 0 |
| Myles Straw | 0 |
| Garrett Stubbs | 0 |
| Dustin Garneau | 0 |
| Abraham Toro | 0 |
