| Player's Name | Homeruns |
| George Springer | 123 |
| Alex Bregman | 116 |
| Jose Altuve | 115 |
| Yuli Gurriel | 108 |
| Carlos Correa | 107 |
| Josh Reddick | 81 |
| Michael Brantley | 73 |
| Yordan Alavrez | 55 |
| Evan Gattis | 50 |
| Robinson Chirinos | 33 |
| Kyle Tucker | 14 |
| Max Stassi | 13 |
| Martin Maldonado | 13 |
| Brian McCann | 13 |
| Jake Marisnick | 8 |
| Tyler White | 4 |
| Tony Kemp | 3 |
| Aledmys Diaz | 3 |
| J.D. Davis | 1 |
| Derek Fisher | 1 |
| Taylor Jones | 0 |
| Myles Straw | 0 |
| Marwin Gonzalez | 0 |
| Garrett Stubbs | 0 |
| Dustin Garneau | 0 |
| Abraham Toro | 0 |
